{"id":376765,"date":"2023-08-16T08:05:38","date_gmt":"2023-08-16T06:05:38","guid":{"rendered":"https:\/\/www.pcnen.com\/portal\/?p=376765"},"modified":"2023-08-16T08:05:38","modified_gmt":"2023-08-16T06:05:38","slug":"estrogenski-receptor-u-srcu-regulise-gojaznost-kod-zena-u-postmenopauzi","status":"publish","type":"post","link":"https:\/\/www.pcnen.com\/portal\/2023\/08\/16\/estrogenski-receptor-u-srcu-regulise-gojaznost-kod-zena-u-postmenopauzi\/","title":{"rendered":"Estrogenski receptor u srcu reguli\u0161e gojaznost kod \u017eena u postmenopauzi"},"content":{"rendered":"<p>Poznato je da estrogen igra va\u017enu ulogu u za\u0161titi \u017eenskog srca, ali kad \u017eene u\u0111u u postmenopauzu i nivo estrogena padne, izlo\u017eene su pove\u0107anom riziku od niza bolesti i stanja, uklju\u010duju\u0107i bolesti srca, gojaznosti i dijabetes.<\/p>\n<p>Objavljena u Nature Cardiovascular Research, studija je otkrila da je smanjena ER\u03b1 u \u0107elijama odgovornim za sr\u010danu kontrakciju (kardiomiociti) dovela do umjerene sr\u010dane disfunkcije i pove\u0107ane stope gojaznosti kod \u017eenki mi\u0161eva, ali ne i kod mu\u017ejaka mi\u0161eva, <a href=\"https:\/\/znanost.com.hr\/zdravlje-i-medicina\/3\/estrogenski-receptor-u-srcu-regulira-pretilost-kod-zena-u-postmenopauzi\/3354\" target=\"_blank\" rel=\"noopener\">prenosi<\/a> Znanost.com.hr.<\/p>\n<p>Geni koji su va\u017eni za kontraktilnost srca i metaboli\u010dku funkciju srca tako\u0111e su bili ni\u017ei u \u017eenskom srcu kada je ER\u03b1 bio smanjen, obja\u0161njavaju\u0107i za\u0161to srca \u017eena u studiji nisu tako dobro pumpala.<\/p>\n<p>Vanredni profesor David Greening, stru\u010dnjak za biologiju izvan\u0107elijskih <a href=\"https:\/\/bs.wikipedia.org\/wiki\/Vezikula\" target=\"_blank\" rel=\"noopener\">vezikula<\/a> na Univerzitetu La Trobe, je rekao da \u010destice, nazvane izvan\u0107elijske vezikule, koje su otpu\u0161tene iz \u017eenskih srca sa smanjenim ER\u03b1 tako\u0111e sadr\u017ee proteine koji se razlikuju i od kontrolne grupe i od mu\u0161kih srca.<br \/>\n&#8220;Otkrili smo da smanjenje ER\u03b1 u \u0107elijama sr\u010danog mi\u0161i\u0107a (kardiomiocitima) \u017eenki mi\u0161eva dovodi do transkripcijske, lipidomske i metaboli\u010dke disregulacije u srcu, zajedno s metaboli\u010dkom disregulacijom u skeletnim mi\u0161i\u0107ima i masnom tkivu&#8221;, rekao je profesor Greening.<\/p>\n<p>Nau\u010dnici poru\u010duju da sada kada bolje razumiju ER\u03b1, imaju ve\u0107e \u0161anse da odredei terapije za sprje\u010davanje pojave gojaznosti.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poznato je da estrogen igra va\u017enu ulogu u za\u0161titi \u017eenskog srca, ali kad \u017eene u\u0111u u postmenopauzu i nivo estrogena padne, izlo\u017eene su pove\u0107anom riziku od niza bolesti i stanja, uklju\u010duju\u0107i bolesti srca, gojaznosti i dijabetes.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-376765","post","type-post","status-publish","format-standard","hentry","category-svastara"],"_links":{"self":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/376765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/comments?post=376765"}],"version-history":[{"count":1,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/376765\/revisions"}],"predecessor-version":[{"id":376768,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/376765\/revisions\/376768"}],"wp:attachment":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/media?parent=376765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/categories?post=376765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/tags?post=376765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}