{"id":298390,"date":"2020-07-31T13:46:37","date_gmt":"2020-07-31T11:46:37","guid":{"rendered":"https:\/\/www.pcnen.com\/portal\/?p=298390"},"modified":"2020-07-31T13:46:37","modified_gmt":"2020-07-31T11:46:37","slug":"otkrivena-ahilova-peta-virusa-korona","status":"publish","type":"post","link":"https:\/\/www.pcnen.com\/portal\/2020\/07\/31\/otkrivena-ahilova-peta-virusa-korona\/","title":{"rendered":"Otkrivena &#8216;Ahilova peta&#8217; virusa korona"},"content":{"rendered":"<p>Me\u0111unarodna grupa nau\u010dnika pod rukovodstvom hrvatsko-njema\u010dkog nau\u010dnika Ivana \u0110iki\u0107a je objavila u vode\u0107em svjetskom nau\u010dnom \u010dasopisu Nature studiju u kojoj je esenicijalni enzim korona virusa SARS-CoV-2 opisan kao njegova &#8220;Ahilova peta&#8221;,<a href=\"https:\/\/www.jutarnji.hr\/life\/tehnologija\/dikicev-tim-pronasao-ahilovu-petu-korone-studija-je-objavljena-u-vodecem-znanstvenom-casopisu-15011097\"> pi\u0161e Jutarnji list.<\/a><\/p>\n<p>Nau\u010dnici su, tako\u0111e, objasnili razliku izme\u0111u SARS-a (Te\u0161ki akutni respiratorni sindrom) i Kovida-19. \u0110iki\u0107eva studija uvr\u0161tena je i me\u0111u top 10 radova o Kovidu-19 koji su ju\u010de objavljeni u svijetu, navodi dnevnik.<\/p>\n<p>Kada virus SARS-CoV-2 prodre u ljudsku \u0107eliju, podsti\u010de je da proizvodi proteine za stvaranje novih virusa. Jedan od tih virusnih proteina, zvan PLpro (proteaza nalik papainu), neophodan je za replikaciju i brzo \u0161irenje virusa.<\/p>\n<p>Pored toga, SARS-CoV-2 koristi ovaj enzim za prigu\u0161ivanje antivirusnog imunolo\u0161kog odgovora, poma\u017eu\u0107i virusu da oblikuje imunolo\u0161ki sistem doma\u0107ina u svoju korist.<\/p>\n<p>Time se virus mo\u017ee lako umno\u017eavati i \u0161iriti dalje.<\/p>\n<p>Ali, nau\u010dnici pod rukovodstvom prof. Ivana \u0110iki\u0107a ne samo da su identifikovali protein PLpro kao slabu kariku novog korona virusa nego su i otkrili kako se farmakolo\u0161kom inhibicijom toga proteina blokira njegovo umna\u017eanje te ja\u010da antivirusni imunolo\u0161ki odgovor.<\/p>\n<p>Studija u &#8220;Natureu&#8221; rezultat je saradnje \u0110iki\u0107eva tima s Instituta za biokemiju II s Institutom za medicinsku virusologiju pod rukovodstvom Sandre \u010ciesek, a eksperimentalnim podacima, reagensima i savjetima pridonijeli su i drugi nau\u010dnici iz Frankfurta, Minhena, Majnca, Frajburga i Lajdena.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Me\u0111unarodna grupa nau\u010dnika je objavila studiju u kojoj je esenicijalni enzim korona virusa SARS-CoV-2 opisan kao njegova &#8220;Ahilova peta&#8221;<\/p>\n","protected":false},"author":1,"featured_media":298391,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-298390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vijesti"],"_links":{"self":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/298390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/comments?post=298390"}],"version-history":[{"count":1,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/298390\/revisions"}],"predecessor-version":[{"id":298392,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/posts\/298390\/revisions\/298392"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/media\/298391"}],"wp:attachment":[{"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/media?parent=298390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/categories?post=298390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcnen.com\/portal\/wp-json\/wp\/v2\/tags?post=298390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}